So we have the forward contemplation on the causes of suffering, and the reverse contemplation on the non-existence of suffering. In forward contemplation we realize how we come into being and in backward contemplation we realize we have no independent self. Both modes of contemplation are related and it is necessary to complement one with the other. The point of both practices is to learn how to realize cessation, to terminate cyclic existence.
Awakening to true nature, your mind will be unclouded by Ignorance--it will be bright with wisdom. Transcending fundamental ignorance, you will no longer be conditioned by it. This non-conditioning will be true for the remaining links of the chain, one after another. Thereby is birth and death also ended--when fundamental ignorance ceases, ultimately there is also cessation of birth and death.
The Four Noble Truths and the Three Seals