The principle of causes and conditions and conditioned arising definitely holds for samskrita, but what about asamskrita? Here, a subtle distinction must be made. Take, for example, nirvana. From the perspective of ordinary sentient beings, nirvana does arise from causes and conditions. A person practices, and if the causes and conditions are right, then a consequence of his or her practice will be nirvana. However, one who has already attained liberation makes no distinction between nirvana and samsara. An enlightened person, even though he or she can still function in the world, perceives that the world and phenomena have no true existence. In this sense, asamskrita are not dharmas which arise from causes and conditions, and there is no such thing as causes and conditions and causes and consequences.
What I have just said may seem to contradict the Buddhist concept of impermanence, which states that nothing remains unchanged. This concept, however, is from the perspective of ordinary sentient beings. Liberated beings do not perceive a world, sentient beings, or dharmas arising and perishing. For liberated beings, there is no change to speak of.